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Fresher M.sc. Biotechnology : Resume CV. E-mail : ms.anitapatil AT rediffmail.com. Seeking a challenging position to attempt about the methodology, use my skills to the optimum level and at the same time get an opportunity to letter, enhance my knowledge in the field of about for Biotechnology. Master of Science (M.Sc.) Biotechnology [ Fresher] M.Sc. Biotechnology Part II Mumbai University (Birla College, Kalyan) April 2010 First class (62.90%) M.Sc. Business Letter? Biotechnology Part I Mumbai University (Birla College, Kalyan) April 2009 First class (68.40%) B.Sc. For? Biotechnology Mumbai University (Birla College, Kalyan) April 2008 First Class (61.37%) HSC Acharya Bhise Junior College, Shahapur. Feb 2005 First Class (65.83%) SSC G. V. Scripture? Khade Vidyalaya, Shahapur. Attempt An Essay About The Methodology? March 2003 First Class with Distinction (82.00%) Title : Studies in hormonal control of annotated differentiations in Garcinia indica.
Location : PTC Division, National Chemical Laboratory, Pune. Project summary : Mature seeds of Garcinia indica were excised from mature fruits and cultured on woody plant medium with different concentrations of attempt an essay the methodology BAP. Somatic embryos were obtained within a period of annotated mla bibliography 2-3 weeks. Embryo induction was observed all over the explant surface. Origin of attempt about for embryo and effect of concentration of mla bibliography BAP on somatic embryogenesis was confirmed histologically.
Germination and elongation of these embryos was also achieved on the medium supplemented with BAP. Plant tissue culture techniques : Preparation of media, sterilization of explant, inoculation, subculturing and maintenance of explants. Animal tissue culture techniques : Trypsinization. Microbial techniques : Media preparation, plating, staining of organism. Histological techniques : Paraffin sectioning of tissue. Attempt An Essay For? Immunological techniques : ELISA, RIA. Molecular techniques : SDS- PAGE, AGE, Isolation of DNA. Chromatographic techniques : Paper chromatography, TLC, affinity chromatography. Name : Anita Ashok Patil. Mailing Address : B/203, Padmabhaskar Complex, Near Vasind Railway Station, Gerase Road, Vasind (East), Tal: Shahapur, Dist: Thane.
Marital status : Single. Languages Known : English, Hindi, Marathi. By Sandra Cisneros? Interest : Listening music, Cooking, Reading. Email ID : ms.anitapatil AT rediffmail.com. To seek a challenging position in an Industry, that offers opportunities for personal contribution and professional growth, where my knowledge and management skills will be fully utilized and attempt about, further developed with steady learning through on-the-job experience in core application development projects. MSc in Biotechnology with 2 years of experience in financial and medical underwriting of life insurance products with Birla Sun Life Insurance Pvt Ltd, India. Active participation in teamwork.
Always looking forward to learn absorb new things and apply innovative ideas. Work under pressure and always within TAT (Turn Around Time) with persistent speed. Pursue work with energy, drive, and a need to reach the target. Particulars College Name University / Board Year of Passing % Secured M. Sc. (Biotechnology) Birla college of Arts, Science and Commerce Mumbai 2008 70.4% (Distinction) B. Sc. (Biotechnology) S. I. E. Report? S. An Essay About? College Mumbai 2006 74.37% H. S. Letter For University? C. (Science) Kirti College Maharashtra 2003 78.19% S. S. C. Convent Girls’ High School Maharashtra 2001 83.06% Birla Sun Life Insurance Co. Ltd. Established in 2000, Birla Sun Life Insurance Company Limited (BSLI) is a joint venture between the Aditya Birla Group and Sun Life Financial Inc, leading international financial services organization from Canada. BSLI has contributed significantly to attempt the methodology, the growth and development of the application, life insurance industry in India and currently ranks amongst the top 5 private life insurance companies in the country. Executive - Life Underwriting ( Nov. 09 to Sept.
10) Executive - Health Underwriting (Aug. 08 to Nov. 09) Review and summarize applicant's medical information such as attending physician Statements, Lab reports, paramedic exams and/or other related underwriting information consistent with the about, company's standards. Provide clear file documentation so that Prudent Risk is taken by the company without loss to company. Scrutinizing the New business proposal forms by assessing the medical and financial status give the Underwriting decision to issue the annotated mla bibliography, policy or not.. Empowered with underwriting authority limit, for Life insurance, of 10 lakh Sum Assured including medically Sub Standard cases up to class 2 rating (i.e. charging extra premium within my limit). Empowered with underwriting authority limit, for Health insurance, of 2 lakh Sum Assured by Swiss Re Health Reinsurer. Strict adherence to TAT even during year end. For? Reverting to queries brought forward by the sales support team and various branches within TAT. Made Seminars related to various Life Insurance products and also medical topics related to Life and report, Health Insurance Underwriting. Handling individual, Partnership, HUF, Employer-Employee, high Sum Assured cases that provides high premiums to the company.
Done Re-insurer audit of Underwriting for 1 month. Prepared Daily M.I.S. (Management Information System). Successfully completing level wise trainings given by the functional department and corporate training department with respect to personality development, Goal Orientation, Goal setting and effective communication skills. Also undergone many E-learning Courses. Completed training by Swiss Re (Reinsurer).
Attending underwriting meetings and about for, discussing different types of risk analyzed with senior managers. Regular revision of underwriting manuals and guidelines with senior managers and noting of current updates. Cleared Licentiate exam in Nov. 09 conducted by Insurance Institute of India. Cleared Associate exam (1st paper) in May. Analyst Cover Letter Uk? 10 conducted by Insurance Institute of attempt about the methodology for India. Cleared ALU 101 (Academy of Life Underwriting) in plagiarism report turnitin Apr. 10, conducted by Canadian Institute of Underwriting. Completed MSCIT Course in Dec. 04 conducted by Maharashtra State (Computer Fundamentals, Windows/ MS Office, Internet) Computer proficient, good presentation skills, excellent skills in Word and Excel, able to use pivot table, write formulae, etc.
Have done a Project at an essay, L.N.M.S, Tata Memorial Hospital, B.A.R.C-Parel, titled ‘‘Application of Radiorespirometry methods in laboratory diagnosis of Tuberculosis and to Study drug susceptibility of Mycobacterium Tuberculosis (for 5 months during PG) Also attended various workshops and trainings at Haffkine Institute, Dept of Assisted Reproduction and Genetics at Jaslok Hospital, Maharashtra Institute of Science - J.J. Hospital, CREMERE (Applied Genetics and Genetic Counseling). Successfully scaled 13000 feet in the Gharwal Himalayan ranges (Valley of flowers Hemkhund Sahib – In Uttarakhand) in improving thinking July 2010 by SAVE Nature group approved by Indian Mountaineering Foundation, New Delhi. Scaled many peaks in Maharashtra. Took part in various competitions like pot making, lantern making, Christmas crib making and about for, won many prizes at Birla Sun life Insurance. The Secret Scripture? International Symposium on Emerging Trends in Genomic Proteomic Sciences during post graduation. Attended Biogerant-06”Sectorwise analysis of Indian Biotech Industry.”(S.I.E.S.) Participation in Intercollegiate Quizzes in Biogerant, Vivekanand Education society, K.J.Soumaiya College and attempt an essay about the methodology, Galazio at Khalsa college (Event-Train your Brain). Received a Prize for Applied components (drugs and dyes) in T.Y.B.Sc. Won 1st prize in ‘Bioquiz (Biozeal)’ held at Thadomal college (TSEC), Bandra . Effective time management and cooperation skills.
Ability to annotated, liaise with all levels of management. Good written and attempt about the methodology for, oral communication skills. Application? A passion for technology, willingness to work hard, energetic, and of course, a desire to be the best. Attempt The Methodology For? Date of Birth : 10th April, 1985. Address : 14/2, Pandit Nivas , S.K.Bole Road, Dadar (West), Mumbai – 400 028.
Phone : 09773504352 / 09819435757. Email ID :dharabaua AT gmail.com. Fresher M.sc. Biotechnology : Resume CV. Address - 3/A Sadhana Society. E-mail - aminmrugesh AT gmail.com. Date of birth- 2nd January 1984. Improving Thinking Introductory? Language - Fully literate in English, Guajarati and Hindi. Attempt An Essay About? Field of critical specialization- Master of Science in Biotechnology. Bachelor of Science in an essay Microbiology. To join an industry and dedicate myself for its welfare, considering company goals and mottos in mind.
Also to gain an opportunity to develop myself further and brush my knowledge time by report turnitin, time. It will be my prime priority to make the attempt, organisation to be more famous and prestigious by my hard and sincere work. The Secret Scripture Essay? 2008-2010 Master Of Science In Biotechnology. Charotar Institute of Applied Science, Changa (Gujarat University) First Year – SECOND CLASS. Final Year – SECOND CLASS.
2005-2008 Bachelor of Science in Microbiology. The Methodology For? J And J College Of Science, Nadiad (Gujarat University) First Year – FIRST CLASS. Second Year– FIRST CLASS. Final Year – SECOND CLASS. Report Turnitin? Title : Studies on Microbial Siderophore. Description : - Siderophore is iron specific ligand produced by organisms when iron is low in environment. It has lots of application in different field such as in drug delivery by conjugate with drugs. In many diseases it use such as malaria, hemochromatosis, in -thalassemia, and also removal of toxic metal and transuranic elements form body. Some siderophore antifungal and antibacterial activity and attempt an essay about, kill pathogenic organisms. In agriculture field it provides iron and other metal ions to plant (PGPR).
I had isolate siderophore producing organisms form soil and main work done was its FT-IR and measure its size my nano particle SIZE ANALYZER also find its antifungal activity against pathogenic fungi. Duration : 1 Year (2009-2010) Place : Department of Biotechnology, Charotar Institute of Applied Science, Changa, India. Guide : Dr. Trupti K. Application Letter For University? Vyas. During Masters - seminars. - Principle and analysis of biological network. - Good manufacturing practices in biotechnology industries. - Awarded for participation in Intra college seminar competition organized by GSBTM, 2007. J and J College Of Science, Gujarat University. - Awarded for participation on attempt an essay about for, poster by J and J College of Science, Gujarat university, 2007-2008. - Computer literate in Windows Operating System and also familiar with Microsoft office, Internet.
Re: Fresher M.sc. Biotechnology : Resume CV. Mla Bibliography? i also done diploma in about medical biotechology. Im also doing project in development of ELISA from NIHFW NEW DELHI. I also done workshop ,they based on enzymes which conducted by NITZA FROM HYDERABAD. - sheetalbhat191 AT gmail.com. Dolphin(P.G)institute of biomedical and natural sciences,dehradun(H.N.B Garhwal university uttranchal) 2010 M.Sc. Biotechnology 71.4% Mangalmay institute of management and technology,Greater noida(C.C.S university,Merrut) 2007 B.Sc Biotechnology 64.36% Govt. Girls High Sec.
School, Mubarak Mandi.Jammu(jk state board of school education) Jagariti Niketan School Kachi chhawni Jammu(jk state board of school education) Presently working with RAVENBEHL PRIVATE LTD, As a QA TRAINEE OFFICER. - In process quality checks at shop floor in tablet, capsule, liquid section. - Monitoring and assurance of plagiarism turnitin process and product/equipment /objectives and requirements. - Review of attempt about the methodology BMR AND BPR before the annotated mla bibliography, dispatch of the attempt an essay about, batch. - Imparting training to essay questions by sandra, the workers and operators as per the standard operating procedure. - Screening of plant extracts using immunomodulatory basic test model for the duration of attempt an essay the methodology 4 months from IIIM (Indian institute of integrative medicines) Jammu,Supervised by Ms. Anamika Khajuria , Scientist pharmacology division. - LYMPHOCYTE PROLIFERATION ASSAY. Improving Thinking? - MACROPHAGE FUNCTION ASSAY. - CYTOKINES BY USING ELISA TEST. - State biotechnology programme at Beehive (P.G) College,Dehradun. - Workshop on about, microbial technology and its applications.at F.R.I Dehradun. - I never base my experiments of life on other’s observations. - I believe in coaxing every type of challenge with zeal confidence. T. KEERTHI PRIYA. e-mail : keerthi.priya26 AT gmail.com. To learn and function effectively in an organization and be able to deliver to application letter, the bottom-line. To constantly upgrade the knowledge and skills and make a difference in the methodology whatever I do. 2011 M.Sc., Biotechnology from Maharajah’s PG.College, Andhra University. Secured an aggregate of 72 % 2009 B.Sc., Degree in Biotechnology, Zoology Chemistry from BGR.Women’s Academy, Nellore, Sri Venkateswara University.
Secured an aggregate of 74 % 2006 Intermediate from Sri Chaitanya Junior College, Nellore, Andhra Pradesh (State Board). Turnitin? Secured an the methodology, aggregate of 87 % 2004 SSC from St.Joseph’s High School, Nellore. Secured an aggregate of critical in an course 82 % Project Work on “Evaluation of Inhibin Alpha gene mutations in individuals with Premature Ovarian Failure” at Institute of Genetics and Hospital for attempt about the methodology Genetic Diseases, Hyderabad. EXTRA CURRICULAR ACTIVITIES. Seminar Presentation, Paper Presentation etc. Listening to in an course, music.
I do hereby declare that the particulars of about the methodology information and facts stated herein above are true, correct and complete to the best of my knowledge and belief. Date : 26-July-2011 ( T. KEERTHI PRIYA ) This is in reference for the post of lecturer in Biotechnology.As i have completed M.Sc. Biotech from Amity University, Noida and wish to teach as a Faculty in mla bibliography the following subject. Copyright 2017 vBulletin Solutions, Inc. Attempt An Essay The Methodology? All rights reserved.
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Sialorrhea and Aspiration Pneumonia: A Case Study. This case study compares two different clinical outcomes for a patient with a long-standing psychotic disorder prescribed clozapine on two occasions. During the an essay about first trial, clozapine was used at the secret scripture essay, a higher dose for this patient (350-450mg/day) and included clinically significant sialorrhea, pneumonia, and pneumonia-like illnesses requiring immediate medical intervention including hospitalization. An Essay About! There were also patient complaints of mla bibliography fatigue, cough, choking, and constipation leading to poor adherence. Clozapine was discontinued when the patient withdrew his consent due to side effects, despite his awareness of its benefits, including reduction of command hallucinations and irritability. The second clozapine trial was associated with lower daily doses and therapeutic serum blood levels. The patient was actively participating in and adhering to the medication plan. A very narrow window of clozapine dose was exceeded for two days and an essay for, the patient complained of hypersalivation, cough, and improving critical, lethargy. Attempt For! He was subsequently hospitalized for a two week period to treat aspiration pneumonia. This hospitalization helped establish the ideal daily dose of clozapine for annotated mla bibliography, this patient and also brought the relationship between aspiration pneumonia and clozapine to the attention of the psychiatrist and medical specialist. Once the appropriate dosage for this patient was established, his psychotic and affective symptoms were controlled, he was not hampered by adverse side effects, and he started to actively participate in social and recreational activities and plans that culminated in discharge from a state psychiatric facility to a supportive community residence.
It is our hope that the lessons we have learned from our shared experience with this patient will be of benefit to other clinicians and patients. This case study compares two different clinical outcomes for a patient with a long-standing psychotic disorder prescribed clozapine on two occasions, from 2005 to attempt an essay about, 2009 and again from business analyst 2010 to 2012. During the first trial, clozapine was used at a higher dose for this patient (350-450mg/day). This trial included clinically significant sialorrhea, pneumonia, and pneumonia-like illnesses requiring immediate medical intervention including hospitalization. There were also patient complaints of fatigue, cough, choking, and constipation leading to poor adherence. Clozapine was discontinued when the an essay patient withdrew his consent, due to scripture, side effects, despite his awareness of its benefits, which included a reduction of command hallucinations and irritability. The second clozapine trial was associated with lower daily doses and therapeutic serum blood levels. The patient was actively participating in and adhering to attempt an essay about the methodology, the medication plan. Clozapine was slowly increased and in essay, two months the daily dose was 200mg. When the daily dose was increased to 225 mg for about the methodology for, two days and 250mg for annotated mla bibliography, an additional two days the patient complained of hypersalivation, cough, and lethargy.
He was subsequently hospitalized for a two-week period to treat aspiration pneumonia. Attempt An Essay The Methodology! This hospitalization helped establish the ideal daily dose of clozapine for this patient and also brought the plagiarism report turnitin relationship between aspiration pneumonia and clozapine to the attention of the psychiatrist and medical specialist. Clozapine was then augmented with quetiapine resulting in the significant clinical improvement of psychotic symptoms (relative to baseline). Lithium was also added to the medication regimen to control affective disorder symptoms. With his psychotic and affective symptoms controlled he started to actively participate in attempt about for, social and recreational activities and annotated, plans that culminated in discharge from a state psychiatric facility to a supportive community residence. It is our hope that the lessons we have learned from our shared experience with this patient will be of benefit to an essay the methodology, other clinicians and patients. This 56-year-old, single, never-married Native-American man had a long history of a psychotic disorder complicated by substance abuse, borderline intellectual functioning, antisocial and borderline personality disorders, and criminal behaviors. He had multiple admissions to civil and forensic psychiatric facilities since 1967 for the evaluation and treatment of depression, suicidal thoughts and/or self-mutilation, selfisolation, and impulsivity. He also experienced severe, disabling paranoia and auditory hallucinations. Application For University! In the attempt for past he made deep cuts (requiring stitches) to his wrists and arms in response to command hallucinations, as well as several suicide attempts including at least one overdose with over-the-counter medications. Just prior to this patient#x02019;s transfer to our state psychiatric center, he had served 15 years in prison for rape and assault with a weapon (knife).
He was due to be paroled, but he admitted to plagiarism report, correctional officers that he felt more comfortable in prison and that if he were released he had anxiety and trepidation that he would rape again and/or kill someone. An Essay The Methodology For! He was admitted to a forensic psychiatric facility to evaluate his statements and then transferred to our state psychiatric facility, on parole, for the secret scripture essay, continued evaluation, treatment and discharge planning. During admissions to forensic psychiatric facilities, his primary psychiatric diagnosis was borderline personality disorder, though in one instance, after cutting his forearm in response to command hallucinations, his primary psychiatric diagnosis was mood disorder, organic, mixed. Unfortunately, other than the attempt an essay about the methodology for diagnosis, no rationale for this diagnosis is provided. Upon admission to our psychiatric center he was diagnosed with major depression recurrent with psychotic features; polysubstance dependence by history; antisocial personality disorder; and borderline personality disorder. When admitted to our state psychiatric center the admission conference established a diagnosis of schizophrenic reaction, paranoid type, rule out psychopathic personality. The patient had been offered multiple trials of for university antipsychotic medication, including perphenazine, thiothixene, risperidone, ziprasidone, and quetiapine. He was prescribed primarily valproic acid as a mood stabilizer but recently valproic acid was discontinued in for, favor of lithium. His antidepressant medication included doxepin, nortriptyline, bupropion, sertraline, and escitalopram. At the time of discharge from our psychiatric center he was not prescribed an antidepressant.
Reportedly he experienced serious side effects with chlorpromazine and thioridazine in the past, and letter transfer, he is considered #x0201c;allergic#x0201d; to these medications, although his medical records do not list these medications as having been prescribed. The patient had the attempt an essay the methodology for following health issues: positive purified protein derivative (PPD) test (a skin test used to questions on eleven by sandra cisneros, diagnose tuberculosis) since 1991 (treated with isoniazid [INH]), edentulous with no hard fruits or vegetables (annual choking/aspiration screens performed over the past seven years show that the an essay about the methodology edentulous patient increased the risk for choking and/or aspiration), status post-surgery (S/P) for cataracts in 2004, and S/P prostatectomy in 2008. Critical Thinking Introductory! A computed tomography (CT) scan in 2010 indicated #x0201c;normal pressure hydrocephalus (NPH) versus mild obstructive hydrocephalus.#x0201d; Consultation with neurosurgery did not recommend surgery. The absence of ataxia and dementia ruled out the attempt an essay the methodology for diagnosis of NPH. Improving Thinking In An Introductory Course! He had a 20-year history of smoking one pack of attempt an essay about the methodology cigarettes per day until our facility became smoke-free in January of 2007. Report! A pulmonary CT scan done in 2008 provided evidence of chronic airway disease. First clozapine trial, 2005 to 2009.
In 2005, this patient was admitted to our state psychiatric center, given medical clearance, and, with the patient#x02019;s consent, started on clozapine. Clozapine was titrated over the next two months to 450mg daily. The most immediate side effect, and most notable, was sialorrhea. The patient also reported significant lethargy and attempt about, constipation. One month after starting clozapine, there were multiple nursing reports that the patient was throwing some doses away. Two months after starting clozapine, the patient was taken to an emergency room at a local hospital after being found unconscious and suspected of having a cerebrovascular accident (CVA).
Examination proved mostly negative, but he was admitted for plagiarism report turnitin, additional testing lasting seven days. Attempt An Essay About! With no other viable alternative explanations, it was determined that the patient had not been taking his clozapine and then resumed use of the 450mg/day prescribed dose. The syncope that had resulted can occur when clozapine is plagiarism titrated up too quickly. 1 Clozapine was discontinued by an essay about the methodology for, the attending physician at the local hospital and scripture, the patient was returned to the state psychiatric center. Shortly after the patient#x02019;s return, clozapine was reordered and titrated to 300mg daily. In 2006, there were mostly complaints from the patient about his medication, such as episodic sore throat, hypersalivation, lethargy, and constipation. For the most part, he was able to manage these side effects with throat lozenges, additional rest, and laxatives. His clozapine blood levels were exceptionally low for his prescribed daily dose. Additionally, we know he used tobacco products at attempt an essay, this time, which may be, at critical in an course, least in part, responsible for the lower blood levels.
2 In January of 2006, he complained of a severe sore throat, cough, and fever. Rales were noted bilaterally, and the possibility of pneumonia was raised. Given that sputum and chest x-rays were negative, the patient was not treated and attempt the methodology for, the symptoms cleared in a few days. In May of 2006, he complained of letter for university a severe cough, and the chest x-ray was essentially negative. Again, his cough cleared in a few days. An Essay The Methodology! There was no attempt to annotated mla bibliography, control his sialorrhea with medication at any time during this first trial. In 2007, additional references to hypersalivation, cough, lethargy, and constipation were noted in his record on daily doses of 350 to 400mg. The facility became a tobacco-free zone during 2007, although most patients were able to about the methodology for, obtain tobacco for the remainder of 2007. Clozapine blood levels remained lower than expected but higher than in 2005 and 2006 ( Figure 1 ). In May, the patient was admitted for two days to scripture essay, a local hospital with chest pain. Scattered rales were noted bilaterally. Hypersalivation, cough, and lethargy were patient complaints.
Pneumonia was considered but x-rays were negative. He was hospitalized again in September with similar complaints and symptoms. Attempt About! In addition to sialorrhea, cough, and lethargy, he had a fever. Mla Bibliography! A chest x-ray demonstrated either atelectasis or a left basal infiltrate. In 2008, daily doses of 350 to an essay the methodology, 400mg were prescribed for the secret essay, this patient.
He continued to an essay about the methodology for, have sialorrhea, cough, and lethargy. There were also two hospitalizations for pneumonia in 2008. The hospital smoking ban was in full effect by this time, and plagiarism turnitin, his serum blood levels continued to move up slowly ( Figure 1 ). In January of attempt about the methodology for 2008, the patient was transferred to a local hospital complaining of shortness of breath, cough, fever, and malaise. The CT scan showed #x0201c;infiltrate within the right lower lobe.#x0201d; He was diagnosed with right lower-lobe pneumonia. He was treated and returned to the state psychiatric center. In September of 2008, the patient was again transferred to annotated mla bibliography, a local hospital for nine days to treat right lower-lobe pneumonia.
He had a productive cough, fever, and an essay about, chills. The initial chest x-ray demonstrated right lower pneumonia, a repeat chest x-ray showed only minimal fluid in the minor fissure. Questions By Sandra Cisneros! Additionally, the an essay about the methodology patient complained of abdominal pain when he presented at essay questions by sandra, the emergency room. A CT scan suggested a significant fecal impaction. The patient often complained of constipation secondary to clozapine. In April of attempt about the methodology 2009, despite a partial therapeutic response, clozapine was discontinued because staff reported difficulty obtaining weekly blood samples. Psychology Course! He was started on a low dose of haloperidol, which was gradually increased in an effort to control his psychotic symptoms. Haloperidol was augmented with olanzapine, valproic acid, and quetiapine over the following year. On these combinations of medications, he reported severe command auditory hallucinations criticizing him and telling him to harm himself or others. He made no attempt to hurt himself or others during this time; however, it was apparent that his response to attempt about, clozapine was more effective in controlling his psychosis.
Literature review. Kane and Correll 3 demonstrate two central points: that an effective approach considers current symptoms, past therapeutic response, adverse effects, patient choice and expectations, and that clozapine is the only evidence-based treatment for psychology, refractory patients. Farka and Azorin 4 add that clozapine is the treatment of choice for patients with schizophrenia who are refractory to an essay the methodology for, treatment, display violent behaviors, or at cover uk, high risk for suicide. There are serious and sometimes fatal adverse effects associated with the for use of clozapine. Agranulocytosis, seizure activity, myocarditis, cardiomyopathy, metabolic syndrome, diabetes mellitus, fever, and neuroleptic malignant syndrome (with clozapine alone or when used in combination with lithium or other central nervous system [CNS] drugs) are the letter for university more well-known and severe adverse effects. Orthostatic hypotension, sialorrhea, constipation, and somnolence are also considered common but less serious. 5 , 6 Additional events observed possibly related to clozapine are coughing, pneumonia, pneumonia-like symptoms, aspiration, pleural effusion and pneumonia, and lower respiratory tract infection, which may be fatal. 6. The adverse effects of sialorrhea, aspiration pneumonia, and pneumonia-like illnesses are central to our discussion. Pathophysiology and management of clozapine-induced sialorrhea are reviewed by Praharaj, Arora, and Gandotra and Hussaini.
7 , 8 Sheriff et al 9 note that there is still room for additional research on clozapine-induced hypersalivation. Aspiration pneumonia and pneumonia-like illnesses and their association to clozapine are increasingly being addressed in the literature. 10 - 13. Hypersalivation is the most prominent side effect associated with the attempt an essay about for use of clozapine. Approximately 30 to plagiarism, 50 percent of patients prescribed clozapine will report sialorrhea. The question is why, especially given the strong anticholinergic properties of clozapine. 1 , 5 Early studies did not find a significant difference between the saliva flow rate between healthy controls and those prescribed clozapine.
14 , 15. More recently, the about the methodology for evidence seems to suggest that clozapine does in fact increase the saliva flow rate; however, there was no correlation between salivary flow rate and mean clozapine dose. 16 Ekstrom, Godoy and Riva#x02019;s animal study found the overall actions of clozapine suggested salivation increased during sleep and at rest, but decreased during meals. 17 Clozapine also caused secretion by direct action on muscarinic (M1) receptors of acinar cells, a response independent of central nervous mechanisms, presynaptic intraglandular events, and circulating catecholamines. It appeared likely that the net effect is an thinking introductory course increase in saliva production with clozapine, which may increase the attempt an essay about the methodology risk for aspiration pneumonia, especially for those who also experience swallowing difficulties, a side effect also often associated with clozapine. When Rabinowitz et al 15 found that clozapine did not increase saliva flow rate, they hypothesized that drooling, choking, and on eleven by sandra cisneros, aspiration may result from interference disrupting signals to the brain that the oral cavity needs to be cleared in order to an essay the methodology for, swallow. Pearlman 18 reported that a patient with significant nighttime drooling and episodes of awakening with sensations of choking on his saliva had reduced pharyngeal peristalsis demonstrated by a barium swallow study. However, he noted that instruction in swallowing two or three times without inhaling alleviated the choking sensation without affecting the sialorrhea, leading him to suggest that the application letter for university transfer risk of choking would be better handled by patient education regarding swallowing than by attempt an essay about for, treating sialorrhea.
Hinkes et al 19 reported that a patient developed severe hypersalivation and moderate sedation secondary to clozapine with subsequent pneumonia. They speculated that the sedation and hypersalivation, in combination with pharyngeal/esophageal peristalsis, may have led to the aspiration of the oral contents. They suggest that a reduction in clozapine dose when patients develop sialorrhea and sedation secondary to clozapine could reduce the risk of life-threatening aspiration pneumonia. McCarthy and Terkelson 20 report two cases in which esophageal dysfunction developed when clozapine was the only treatment agent. One case was complicated by hypersalivation; one was not. Importantly, both individuals responded well to introductory psychology, reduced daily doses of clozapine. Swallowing was greatly improved with no significant subjective complaints voiced by the patients. Kuo#x02019;s group 10 looked at the association between second-generation antipsychotics and the risk of pneumonia requiring hospitalization in attempt about the methodology, non-geriatric patients with schizophrenia. Current use of clozapine was found to be associated with a dose-dependent increased risk of pneumonia. Annotated! Quetiapine, olanzapine, and an essay the methodology for, risperidone were also found to be associated with increased risk of pneumonia with no clear dose-dependent relationship.
There was also an essay on eleven cisneros increased risk of pneumonia if clozapine was used in about for, combination with quetiapine, olanzapine, or risperidone. They noted that while the affinity of clozapine for the M1 receptors is remarkably high, olanzapine and quetiapine showed moderate affinity and risperidone had minimal affinity for the M1 receptor. Thinking Introductory! The adjusted odds ratio (risk of pneumonia) for the medications followed the affinity profile for attempt for, the M1 receptors. They also note that clozapine, olanzapine, and business cover letter uk, quetiapine had high affinity for the histaminergic-1 (H1) receptor and risk ratios for pneumonia, while risperidone had a low affinity for the H1 receptor and the methodology, a low risk ratio for pneumonia. The findings, according to Kuo et al 10 provide some association between pneumonia and H1 receptors, and they concluded that affinities for H1 and M1 are the most plausible explanation for the association between a given antipsychotic medication and the risk of pneumonia. Kuo#x02019;s perspective significantly adds to questions by sandra cisneros, the understanding of the association of atypical antipsychotic medication and the risk of pneumonia. 10 If the Ekstrom, Godoy, and Riva 17 animal model is applicable to human physiology and clozapine actually causes secretion by the direct action on M1 receptors of the acinar cells, instead of attempt an essay the methodology dry mouth we would have increased salivation.
We are not alone in concluding that sialorrhea combined with esophageal hypomotility and sedation could, in report turnitin, certain individuals, lead to aspiration pneumonia. About The Methodology! 19 This mechanism is likely responsible for the pneumonia and pneumonia-like symptoms experienced by our patient. Second clozapine trial 2010 to business analyst letter uk, 2012. Attempt About The Methodology For! Due to application letter, clear therapeutic effects of clozapine for an essay the methodology, this patient, especially reduction of auditory hallucinations and absence of lethal command hallucinations, in October of 2010, the patient was approached with the idea of annotated mla bibliography a low-dose clozapine trial. The patient voiced his concerns about the side effects he had experienced with clozapine and the difficulty in obtaining blood samples from him but acknowledged the positive effects of the medication. He agreed to about for, a trial of clozapine at application transfer, doses around 200mg/day. As the clozapine was initiated and attempt an essay about the methodology for, titrated he was observed closely.
Adherence to taking clozapine was excellent. One month after restarting clozapine at a daily dose of 200mg, the patient was not complaining of lethargy, sialorrhea, or constipation. The dose was titrated to 225mg for two days and questions on eleven by sandra, then to 250mg for two days. After four days at a daily dose over 200mg the patient complained of a sore throat, increased saliva production, and cough. The next day he was hospitalized for the treatment of aspiration pneumonia.
A videofluoroscopy swallowing study was performed during this hospitalization. It demonstrated residual matter in the patient#x02019;s oropharynx, prolonged pooling of the bolus, and attempt an essay the methodology for, a delay in plagiarism report turnitin, the swallowing reflex. Recommendations to prevent repeated aspiration pneumonia for this patient included a percutaneous endoscopic gastrostomy (PEG) tube (no oral feedings) or use of a pureed diet. The client objected to both options, though finally agreed to the pureed diet. The patient was returned to an essay, the psychiatric center still on a daily dose of 250mg of clozapine. Immediately the dose was lowered to 75mg daily and gradually increased to 200mg daily. At 200mg daily the annotated patient, as earlier in attempt about, the second trial, did not complain of lethargy, sialorrhea, or constipation.
However, a year later at a time when he was experiencing increased auditory hallucinations and the secret, irritability, the about for dose was increased once again to 250mg for two days. By the second day, the annotated mla bibliography patient reported cough and attempt an essay the methodology, lethargy. His temperature was 101.1#x000b0; F. He was not hospitalized but his daily dose of clozapine was reduced to 200mg and within a few days his cough and other symptoms resolved. With a daily dose of clozapine at 200mg for the following year until present, the patient has not experienced lethargy, constipation, sialorrhea, and/or aspiration pneumonia. A follow-up videofluoroscopy swallowing study was essentially normal as well. Clozapine was then augmented by quetiapine in the second trial resulting in the significant clinical improvement. Lithium was also added to control symptoms of his affective disorder, specifically irritability. With his psychotic and application letter for university, affective symptoms controlled, he started to actively participate in attempt an essay about, social and recreational activities as an inpatient.
He was discharged to a supportive community residence on plagiarism report clozapine 200mg/day, quetiapine 100mg/day, and lithium 600mg HS. He had been on this combination for at least the past year. Use of a lower clozapine dose. As noted above, the side effects in the second trial were primarily addressed with lower doses of clozapine. Reducing the dose of clozapine to reduce associated side effects is currently supported in the literature and has been for many years. 1 , 5 , 19 , 21 , 22. While there was significant improvement in the client#x02019;s symptoms of psychosis, he still reported occasional hallucinations. Therefore, with the patient#x02019;s consent, the dose was increased over four days to attempt an essay, 250mg PO daily. Almost immediately, hypersalivation and cough were noted and the patient was hospitalized for the treatment of aspiration pneumonia.
Hinkes 19 reported a case of aspiration pneumonia in a patient taking 250mg of clozapine daily as well. Substantial symptom reduction in this case occurred with the annotated lower dose of clozapine and without the untoward effect of aspiration. Therapeutic drug monitoring of clozapine serum levels. Although studies indicate a linear relationship between dosage and attempt an essay the methodology for, serum clozapine up to 1000ug/L with low intra-patient variability in individual patients, there can be a 45-fold difference in serum clozapine levels on the secret the same dose between patients (e.g., a 300mg dose of clozapine can result in serum levels between 200ng/mL and 600ng/mL. 23 - 25 Previous studies mostly agree with Nielsen et al 21 that in case of partial response or non-response, the attempt about the methodology for use of therapeutic drug monitoring of clozapine is recommended. A minimal plasma level above the therapeutic threshold of 350 to business analyst uk, 420ng/mL is attempt an essay about necessary to determine nonresponse to clozapine.
21 , 26 , 27 These studies also found no added value in exceeding the upper therapeutic level as it would not improve the clinical response but would increase the potential for adverse effects. A more recent article is also in agreement with the 350ng/mL serum lower level; however, it states that the upper level that corresponds to toxicity remains unclear. Report Turnitin! 28 They suggest that levels between 350 to 1000ng/mL achieved through slow titration are likely to be effective and less likely to cause toxicity. However, they note that levels above 600ng/mL or rapid titration are associated with seizures. They recommend ongoing monitoring when a patient is prescribed higher doses of attempt about the methodology for clozapine (i.e., #x0003e;600mg daily), there has been a change in introductory psychology course, the patient#x02019;s concomitant medication or cigarette use, and when there is suboptimal response. During the about first three years (2005-2007) the patient#x02019;s serum levels were low considering the prescribed dose. The patient#x02019;s partial adherence and use of application letter for university cigarettes are probable explanations. In 2008, the clozapine levels are elevated, though still in attempt about the methodology for, the therapeutic range, at letter transfer, doses similar to what was prescribed in 2007. As noted above, the hospital-wide smoking ban was in effect at this time and the higher levels are likely to be a reflection of his smoking cessation.
2 , 29 , 30 It was in attempt the methodology, 2008 that he developed serious respiratory issues including pneumonia and aspiration pneumonia requiring hospitalization. There was never a period during the first trial where he did not have some degree of mla bibliography hypersalivation while using clozapine. Attempt About The Methodology! It is turnitin likely that the upper level that is tolerable before serious side effects for this individual is an essay about well below the business letter uk quasi-established upper limit of 1000ng/mL. The second trial began with adherence and with the patient remaining a nonsmoker. Mostly the patient was prescribed 200mg daily and the serum blood levels were in the 330 to 350ng/mL range. As noted previously, he was a partial responder at this level but side effects, even sialorrhea, were nonexistent.
Two attempts to increase his clozapine to 250mg daily did not significantly improve his clinical presentation, but did cause develop serious side effects including one instance of aspiration pneumonia requiring hospitalization. Unfortunately, a blood level is not available around the time he was hospitalized. But, around the second time he developed significant respiratory problems with a dose of 250mg daily, his blood level 523ng/mL. It appears from this level that moving beyond a blood level of 400 to 450ng/mL predicts serious side effects for this individual. Maintaining serum levels that are in the lower acceptable limits, even though only partially therapeutic, limits the side effect burden for him. Augmentation with another antipsychotic medication. An Essay About The Methodology! Goff and annotated, Dixon 31 state when patients fail to an essay about the methodology, respond to an adequate dose of an antipsychotic, clozapine is the only option with established efficiency. The problem is that there are a substantial number of patients, estimated to on eleven cisneros, be around 30 to 50 percent, refractory to antipsychotics who will also be refractory or only partial responders to clozapine. 21 , 32 , 33 In this case, how does one proceed? It is an essay about important to note that there is still a question a full 23 years since the FDA approved clozapine whether or not clozapine is the answer for a substantial number of treatment-resistant people with schizophrenia. Goff and business cover, Dixon 31 suggest that in an essay, these situations clinical judgment combined with patient preference must take over when treatment algorithms fall short.
Clinical experience holds that when clozapine is ineffective or not an annotated option for a patient, the art of psychopharmacology comes into play. Given that clozapine is attempt typically used in treatment-resistant schizophrenia, combinations of medications that include clozapine are often tried if clozapine monotherapy is unsuccessful. The addition of another agent can help to lower the dose of clozapine and potentially help with lowering the side effect burden. Augmenting clozapine with other antipsychotics if a patient is a partial responder to clozapine is, though reluctantly, supported by annotated mla bibliography, the current literature. 21 , 22 , 34 - 36. After discussing the rationale for the methodology, augmentation with our patient, he agreed to annotated mla bibliography, a low dose of quetiapine in the second clozapine trial. There is some support for the use of an essay the methodology quetiapine in annotated mla bibliography, combination with clozapine for treatment-resistant patients.
35 The choice of for quetiapine, however, is strictly the essay questions on eleven by sandra cisneros prerogative of the prescriber. For this patient, the combination was quite helpful in controlling his positive symptoms of psychosis. Lithium was also added to the medication plan primarily to address the affective component of our patient#x02019;s psychiatric illness and not necessarily to augment the attempt clozapine. There is support in essay, the literature for using lithium in attempt, combination with clozapine. Buckley 21 cited evidence from essay by sandra cisneros uncontrolled trials that lithium enhanced the antipsychotic effect when added to a stable dose of clozapine. An Essay The Methodology! This was particularly beneficial for patients with a major affective component to their illness. There were also some additional concerns relative to this combination of medications (e.g., seizures and neurotoxicity even with lithium levels #x0003c;0.5mEq/L). This added to the importance that this patient continue to cover letter uk, receive very close monitoring for attempt an essay the methodology, potential side effects. This case suggests a relationship between clozapine dose and vulnerability to aspiration pneumonia. Individual responses to medications have an impact on clinical efficacy and the presence and severity of associated side effects. Further research is needed to clarify this association.
Monitoring aspiration and dose while on clozapine may be of importance for many patients. As a result of our clinical experience with this patient we have ascertained that using tightly controlled pharmacological monitoring and prescribing a finely tuned titration of clozapine dose can result in controlling sialorrhea, and scripture essay, that an effort to rechallenge a patient on clozapine is feasible even when severe sialorrhea and complications arising from it have occurred previously. FUNDING: There was no funding for about, the interviews, development, and writing of improving introductory psychology this article. FINANCIAL DISCLOSURES: The authors do not have conflicts of interest relevant to the content of this article.
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4 Essay Contests With Impressive Prizes: Win an Inn, Farm or Movie Theatre. You can accomplish a lot with your words. You can earn a living, build a brand, even become location independent, all by wielding your writerly capabilities to engage, inspire and persuade. And thanks to a new trend, you can now also use your words to win a fully established business. Awarding a business to the winner of an essay contest is becoming a popular way for small business owners to find a next-in-line who will care for the company as much as they do. Attempt An Essay The Methodology For. It allows them to discover candidates who are passionate about the questions, industry but might not be able to afford to buy the business, while also drumming up a little extra cash for the next stage of their lives. As a bonus, the publicity generated by an essay about, essay contests with such huge rewards can be a boost for thinking psychology, the business. If you’re eager to try your hand at running an inn, farm or movie theatre, here are four appealing businesses you can win via essay contest. One of the first contests to surface as part of this trend this year, the Main inn essay contest was announced when Janice Sage decided to retire after 22 years as innkeeper of Maine’s Center Lovell Inn and Restaurant.
She herself won the inn in an essay contest in 1993, so she opted to attempt about for go the business uk, same route to an essay about find her successor. Analyst Cover Uk. What you can win: A BB worth $900,000 with seven guest rooms, 10 staff members and more than 100 dinner guests on busy evenings. An Essay About The Methodology. This isn’t for someone with zero experience who thinks running a bed and breakfast would be a neat hobby; you can expect to annotated be on-duty up to 17 hours a day and must keep the inn and attempt an essay about the methodology restaurant open for at least a year before you’re free to turn it into something else (if you choose). If 7,500 or more entries are received, you’ll also win $20,000 to put towards running the inn. How to apply: Submit an essay of 200 words or less on the theme, “Why I would like to own and annotated operate a Country Inn.” Sage will choose her top 20 favorites based on “grammatically correct entries that show a passion for work;” from there, an impartial judging duo will select the attempt the methodology for, winner “on the basis of structure of essay (introduction, body and conclusion), creativity, thought and critical thinking in an introductory psychology the conveyance of capability and desire to operate a Country Inn.” Further contest details, including the attempt an essay about for, entry form, can be found here.
Entry fee: $125. If fewer than 7,500 entries are received, this fee will be refunded to you. Deadline: June 6, 2015. If you’d rather work with animals than people, check out Leslie and Paul Spell’s contest to business analyst cover uk give away their goat farm, Humble Heart Goat Dairy Creamery. The Spells tried the traditional route of selling the farm, but they found buyers who seemed the most passionate didn’t have the funds to afford the asking price. So they took to the internet to create an essay contest that would allow interested parties to win the farm instead. The Spells are also hoping to attempt an essay about the methodology for raise enough money to pay off the rest of annotated, their mortgage; if they get $5,000 entries at $200 apiece, they’ll earn $1 million, enough to cover the mortgage and their retirement. What you can win: A 20-acre goat farm in Elkmont, Alabama, worth $345,000, including 85 goats and all farm equipment, plus training during the first half of November for anyone not familiar with the business of making goat cheese. If 2,500 eligible entries are received, the winner will also get a check for $20,000. How to attempt an essay about the methodology apply: Submit an essay of letter for university transfer, 200 words or less describing why you are “the perfect fit to continue the farmstead goat cheese tradition.” The Spells will choose their top 20 essays, which will go on attempt the methodology, to a panel of three independent judges for final selection.
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You can follow her on Twitter and Facebook and hire her services here. Free-writing is a simple method to an essay unleash your words onto the page. This workshop, led by Cynthia Morris, kickstarts your writing habit with daily prompts. Hi, it seems like the deadline for the first contest is not June 6, 2015 but May 30th. Okay, but they#8217;re not exactly #8220;giving away#8221; the properties, are they? Giving away the horse farm for a hoped-for 5000 entries at $200 gets them $1M, as mentioned above, which would seem to be a great improvement over selling the property which is admittedly only thinking introductory psychology course worth $600,000. An Essay About. Gambling $200 for mla bibliography, a 1 in 5000 chance of getting it is about the methodology for, a little rich for my taste but more power to them, as it may suit some people with money to spare for such a long-shot. Similar idea to the lottery. I won#8217;t be entering. Better odds than a lottery!
Odds of dying from choking: 4404 to essay 1. Odds of dying in a car accident: 272 to 1. Odds of winning the lottery: 18 million to 1. Odds of attempt about for, writing a NYT bestseller: 220 to 1. Odds of winning a property in turnitin, an essay contest: Abt. 5000 to 1. The difference is the attempt the methodology, random, accidental nature of the previous 3, whereas, the questions, odds associated with writing are about skill. I#8217;m in. The odds of winning are not #8220;5000 to 1.#8221; In fact, the odds here cannot be calculated at all since this is attempt the methodology for, a skill contest and not a sweepstakes.
The winning essay will be the one judged to be the best, with absolutely no regard as to how many entries there are. Odds can only be calculated for sweepstakes, not for true contests. Well.. If your counting the horses and letter for university transfer live stock your making out prettying good.. Attempt An Essay. Thank you for sharing. really appreciate. Business Cover Letter Uk. This is an exciting new trend. We are running an Essay Contest to WIN our business! Prize: The entire prize will be shipped from Gig Harbor, WA to the winner free of attempt an essay, cost anywhere within Continental United States.
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